ADDITIONAL FILE 1 A comparison of approximation techniques for variance-based sensitivity analysis of biochemical reaction systems APPROXIMATION METHODS AND IMPLEMENTATIONS
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چکیده
In this document, we present several methods for approximating the indices σj and ηj associated with the second-order variance-based sensitivity analysis technique discussed in the Main text. We first review a number of multivariate representation schemes for the response function of a biochemical reaction system that can be used to analytically map the complex relationship between the biochemical factors and the system response. We then discuss how to use these schemes in order to approximate σj and ηj . Finally, we present details regarding the numerical implementation of the resulting approximation techniques.
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تاریخ انتشار 2010